Adding some certain compound to certain chemical reactions, such as: 928-92-7, name is 4-Hexen-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 928-92-7. 928-92-7
[199] To a vial charged with a stir bar were added tm -T-nonenoic acid (143.7 mg,0.9198 mmol), DMAP (23.0 mg, 0.184 mmol), EDC hydrochloride (352.1 rag, 1.840 mmol), and 7.5 mL dry’ dichloromethane under argon atmosphere. Trans-4-hexen-l-oi (216 pL, 1.840 mmol) was added, and the reaction ws stirred for 3 h. The reaction mixture was quenched with a solution of 1 M aq. HC1 (15 mL) after which, the product was extracted with DCM (4 x 15 mL). This organic phase was dried over MgSCL, filtered, and concentrated in vacuo. The product w’as purified by column chromatography (5:95 EtjO: pentane) to yield the product as a colorless oil (201.7 mg, 92% yield). 5H NMR (400 MHz, Chloroform-d)) d 5.52 – 5.36 (m, 4H), 4.08 (t, J~ 6.7 Hz, 2H), 2.31 (t, J- 7.5 Hz, 2H), 2.1 1 – 2.03 (m, 2H), 1.99 (dddd, J= 8.7, 6.5, 3.0, 1.3 Hz, 2H), 1.74 – 1.59 (m,1 OH), 1.42 – 1.26 (m, 4H).,3C NMR (101 MHz, CDCb) d 173.95, 131.28, 129.97, 125.81, 124.86, 63.78, 34.37, 32.39, 29.21, 28.88, 28.66, 28.47, 24.91, 17.94, 17.93.HRMS (EH-): [M] _ CisEbcCb Calculated – 238.1933, Found – 238.1935.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 928-92-7.
Reference:
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; AHMED, Tonia, S.; MONTGOMERY, Patrick, T.; GRUBBS, Robert, H.; (104 pag.)WO2019/113019; (2019); A2;,
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