112-60-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112-60-7, name is 2,2′-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows.
To a cold (0 C) stirred solution of tert-butyl 2-bromoacetate (5.4 mL, 36.6 mmol) and 2,2′-((oxybis(ethane-2,l-diyl))bis(oxy))diethanol (35.0 mL, 203 mmol) in DMSO (50 mL) was added NaH (1.6217 g, 40.6 mmol, 60% in oil) in two portions. The reaction mixture was slowly warmed up to rt, stirred for 23 h, diluted with water (50 mL), saturated with NaCl (50 g), stirred for 5 min, extracted with Et20 (3 x 100 mL), and concentrated. The residue was taken in DCM (50 mL) and water (25 mL), stirred for 5 min. The organic solution was passed through a phase separator, concentrated and purified on a 80 g Si02 cartridge using a gradient of ethyl acetate in hexanes (50- 100%) to afford the title compound (8.2 g, 72.7% yield) as a pale yellow oil. Rf = 0.08 (EtOAc). NMR (400 MHz, CDCb) delta 4.02 (d, J = 1.0 Hz, 2H), 3.75 – 3.60 (m, 12H), 1.47 (s, 9H) ppm.LRMS (ESI) m/z: calculated for Ci4H2807 308.3679; found 330.95 (M+Na)+; Found 347.01 (M+K)+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112-60-7, 2,2′-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol.
Reference:
Patent; QUARTZ THERAPEUTICS, INC.; ZAMBONI, Robert; HENNING, Ryan; JI, Alan; SMITH, Tyler; HELLER, Bradley; REDDY, Thumkunta Jagadeeswar; ROCHELEAU, Sylvain; BEAULIEU, Marc Andre; (266 pag.)WO2018/200981; (2018); A1;,
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