The important role of 111-90-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111-90-0, Diethylene Glycol Monoethyl Ether, other downstream synthetic routes, hurry up and to see.

111-90-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 9; 2-rrriig.2,y)-2-r{r(3.R.3a1y.6ai;Vhexahvdrofuror2.3-61furan-3-yloxylcarbonvnamino)-l- { [Cl ,3-benzodioxol-5-ylsulfonylYisobutyl)amino1methyl| -3- (4-IY2-methyl- 1 ,3-thiazol- 4-yl)methoxylphenyl|propyDoxy1 -2-oxoethyl r2-f2-ethoxvethoxv)ethoxvl acetate; EPO Example 9, step 1; [2-(2-ethoxyethoxy)ethoxy] acetic acid; A mixture of tert-butyl chloroacetate (6.00 g, 40.0 mmol), 2-(ethoxyethoxy)ethanol (2.68 g, 20.0 mmol), 18-crown-6 (250 mg), and sodium hydroxide (12.0 g, 0.300 mol) in dioxane (60 mL) was stirred at room temperature for 24 hours. The dark mixture was diluted with water (250 mL) and twice extracted with ether (50 mL). The aqueous phase was acidified with 12N hydrochloric acid (35 mL) and extracted with dichloromethane (3 x 75 mL). The dichloromethane layers, after combining and concentrating under vacuum, were dried by dissolving in dichloromethane (50 ml) and concentrating under vacuum (3x) to afford [2-(2-ethoxyethoxy)ethoxy]acetic acid as a colorless oil (2.8 g, 73%). 1H NMR (400 MHz, DMSO-d6) delta 3.99 (s, 2H), 3.60-3.38 (m, 9H), 3.38 (q, 2H), 1.07 (t, 3H). ES-LCMS m/z 193 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111-90-0, Diethylene Glycol Monoethyl Ether, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/104646; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts