The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 106-28-5, name is (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol. This compound has unique chemical properties. The synthetic route is as follows. 106-28-5
To the solution of E,E-farnesol (5.0 g, 22 mmol) in anhydrous pyridine (20 mL), acetyl anhydride was added (10 mL) at 0C under argon atmosphere. The reaction mixture was stirred at RT for 12 h. After completion of the reaction, the solution was poured into mixture of water and ice (40 mL) and the product was extracted with ethyl acetate (3×20 mL). Combined organic extracts were washed with saturated aqueous solution of NaHC03, brine and water. Organic layer was dried over anhydrous Na2S04, filtered and evaporated to dryness. EE-Farnesyl acetate was purified by column chromatography using ethyl acetate/hexane (2:98) as eluent to obtain pale yellow oil (5.62 g, 21 mmol, 95%).Analytical results were in compliance with the literature data [Biorg. Med. Chem. 2008, 16, 3108]:Rf= 0.70 (hexane/ethyl acetate, 7:2); NMR (CDCb), delta (ppm): 5.33-5.36 (m, 1H), 5.08-5.11 (m, 2H),,4.59 (d, J = 7.0 Hz, 2H), 1.96-2.13 (m, 8H), 1.71 (s, 3H), 1.68 (s, 3H), 1.60 (s, 3H);13C NMR (CDC13), delta (ppm): 171.0, 142.2, 135.4, 131.2, 124.3, 123.6, 118.3, 61.3, 39.6, 39.5, 26.7, 26.1, 25.6, 21.0, 17.6, 16.4, 15.9.
Statistics shows that 106-28-5 is playing an increasingly important role. we look forward to future research findings about (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol.
Reference:
Patent; INSTYTUT FARMACEUTYCZNY; VitaSynth Sp. z.o.o.; KRAJEWSKI, Krzysztof; KUTNER, Andrzej; DZIKOWSKA, Jadwiga; GUTOWSKA, Jadwiga; NAPIORKOWSKI, Marek; WINIARSKI, Jerzy; KUBISZEWSKI, Marek; JEDYNAK, ?ukasz; MORZYCKI, Jacek; WITKOWSKI, Stanis?aw; BAJ, Aneta; WA?EJKO, Piotr; WO2014/58330; (2014); A2;,
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