The common heterocyclic compound, 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 100-37-8
A mixture of 4-bromoacetophenone (5g, 25 mmol), the diethylaminoethanol (3.5g, 38 mmol), K2CO3 (2g), copper powder (0.5g) and copper (I) iodide (2.5g) in DMSO (30 ML) was heated at 120C until TLC showed consumption of the starting material. After cooling to RT, the mixture was poured onto aqueous NH3 (28 %, 100 ML), extracted with CH2CL2 (3 x 100 ml). The combined organic extracts were dried (NA2SO4), filtered and the CH2CL2 distilled in vacuo. The crude product was purified by column chromatography on silica gel, eluting with EtOAc-MeOH (95: 5) to furnish the pure compound (4.85g, 82%).
The synthetic route of 100-37-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CYTOPIA PTY LTD; WO2003/99811; (2003); A1;,
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