With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, molecular weight is 89.1362, as common compound, the synthetic route is as follows.110-73-6
General procedure: To a solution of 3-formylchromone 5 (1 equiv) in 1,2-dichloroethane was added secondary amine 6a-o (1.2 equiv) and sodium triacetoxyborohydride (1.5 equiv). After stirring at room temperature for 12 h, the reaction mixture was quenched with H2O and extracted with CH2Cl2. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash silica gel chromatography to obtained 4a-n.
Statistics shows that 110-73-6 is playing an increasingly important role. we look forward to future research findings about 2-(Ethylamino)ethanol.
Reference:
Article; Joo, Cheonik; Venkateswararao, Eeda; Lee, Ki-Cheul; Sharma, Vinay K.; Kyung, Min-Sik; Kim, Youngsoo; Jung, Sang-Hun; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5757 – 5762;,
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