Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 612-16-8, name is (2-Methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. 612-16-8
1.02 g (7.38 mmol, 1.0 eq) compound 13c was dissolved in 40 ml CH2Cl2, then 0.84 ml (8.90 mmol, 1.2 eq) PBr3 was added under the condition of ice water bath. After reacting for an hour, a little saturated sodium bicarbonate solution was added to wash the organic phase followed by twice wash with saturated sodium chloride solution, then dried over anhydrous sodium sulfate and desolventizing to gain 1.15 g reddish colored oily material (Compound 8-2c), yield 77.5%. The crude product was used without purification in the next step directly. Compound 8-2a, 8-2b, and 8-2d can be obtained in the same way from compound 13a, 13b, and 13d.
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Reference:
Patent; Fudan University; YE, Deyong; LI, Yali; ZHOU, Lu; WANG, Penghui; CHU, Yong; GONG, Haojun; HUANG, Qi; CHEN, Yan; ZHANG, Zhikuan; (40 pag.)EP3196191; (2017); A1;,
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