Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2002-24-6, name is 2-Aminoethanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. 2002-24-6
9-(2′-hydroxyethylamino)-7-methoxy-1-nitroacridine 7-Methoxy-1-nitro-9-phenoxyacridine (0.69 g) is dissolved in phenol (20 g). Ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 100 C. for 1.5 hour. The reaction mixture is cooled to room temperature, diluted with dry ether (100 ml), slowly poured into dry ether (300 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed twice with ether and crystallized from absolute methanol-ether to give 9-(2′-hydroxyethylamino)-7-methoxy-1-nitroacridine monohydrochloride (0.58 g, 83% yield), m.p. 220 C. (decomp.) 1H NMR (d6DMSO): delta3.45 (t, 2 H, H-2′), 3.65 (t, 2 H, H-1′), 3.80 (s, 3 H, OCH3), 7.30 (dd, 1 H, J1=9.3 Hz, J2=2.5 Hz, H-6), 7.35 (d, 1 H, J=2.5 Hz, H-8), 7.40 (d, 1 H, J=9.3 Hz, H-5), 7.7 (m, 2 H, H-3, H-4), 7.87 (m, 1H, H-2).
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Reference:
Patent; Tiwari, Raj; Miller, Daniel G.; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; US2002/37831; (2002); A1;,
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