3973-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3973-18-0, name is Propynol ethoxylate. This compound has unique chemical properties. The synthetic route is as follows.
4-((2-azidoethyl)amino)-N-(4-fluorophenyl)-N’-hydroxy-1,2,5-oxadiazole-3-carboxamidine (III-4, 0.75g, 2.45mmol) into a 50mL eggplant-shaped bottle,Add 3mL of water and 18mL of acetonitrile solution respectively. Under ice bath, add ethoxylated propynol (290 muL, 2.94 mmol) and cuprous iodide (93 mg, 0.49 mmol),Keep warm and stir for 0.5h, then transfer to room temperature and continue stirring for about 8h.TLC monitored the reaction until the reaction was complete (developing agent: dichloromethane: methanol = 15:1 v/v); the solvent was distilled off under reduced pressure, methanol (20 mL) was added and stirred for 30 min, filtered with suction, and the solvent was distilled off under reduced pressure to obtain a light brown solid , Column chromatography purification (eluent: petroleum ether: ethyl acetate = 2:1 ~ 1:4v/v), to obtain 165mg white solid I-8, the yield was 17.3%,
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3973-18-0, Propynol ethoxylate.
Reference:
Patent; China Pharmaceutical University; Zhu Qihua; Zhang Shan; He Guangchao; Shen Hui; Wang Yiwei; Gu Shuhui; Sun Zeren; Xu Yungen; (24 pag.)CN111138425; (2020); A;,
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