2854-16-2 , The common heterocyclic compound, 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A dichloromethane (0.5 mL) solution of 1-(3-(cyclopropylcarbamoyl)-8-((4-methoxybenzyl)(methyl)ammno)imidazo[ 1 ,2-bj pyridazin-6-yl)- 1 H-indole-3-carboxylicacid (15 mg, 0.029 mmol), 1-amino-2-methylpropan-2-ol (7.86 mg, 0.088 mmol), N,NDiisopropylethylammne (0.026 mL, 0.147 mmol), and HATU (16.76 mg, 0.044 mmol)was stirred at room temperature. After 15 minutes the reaction became a clear brown solution, and was complete. It was concentrated to an oil, then loaded onto a 4g ISCO column for purification by flash chromatography, eluting with 0-100percent ethyl acetate inhexanes. The reaction afforded N-cyclopropyl-6-(3-((2-hydroxy-2-methylpropyl)carbamoyl)- 1H-indol- 1 -yl)-8-((4-methoxybenzyl)(methyl)amino)imidazo[1,2-bjpyridazine-3-carboxamide (17 mg, 0.026 mmol, 90percent yield) as a white solid. LC retention time 0.92 mm [Al. MS (ES+) m/z: 582 (MH).
The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WEINSTEIN, David S.; DUNCIA, John V.; SPERGEL, Steven H.; (76 pag.)WO2018/93968; (2018); A1;,
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