616-29-5, Adding some certain compound to certain chemical reactions, such as: 616-29-5, name is 1,3-Diaminopropan-2-ol,molecular formula is C3H10N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 616-29-5.
General procedure: To a mixture of (3) (1 eq), and different aliphatic diamines (1,2-diaminoethane, 1,3-diaminopropane, 1,4-diaminobutane 4(a-f) and also 1,3-diaminopropan-2-ol) 5a (2.5 eq), phenol (0.5 eq) and a catalytic amount of KI were added. The mixture is heated at 180C for 35min, with completion of the reaction monitored by TLC. Then, the mixture was cooled to room temperature, treated with 5% NaOH solution, extracted with ethyl acetate and finally washed with water and brine. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product. Purification was performed by column chromatography, eluent: CH2Cl2/MeOH: 5-8%, 25%NH3 per 1L.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 616-29-5.
Reference:
Article; Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Silvia; Santos, M. Amelia; European Journal of Medicinal Chemistry; vol. 148; (2018); p. 255 – 267;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts