Extracurricular laboratory: Synthetic route of 402-63-1

According to the analysis of related databases, 402-63-1, the application of this compound in the production field has become more and more popular.

402-63-1 , The common heterocyclic compound, 402-63-1, name is 1-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a 1-Fluoro-3-(1-(4-nitrophenoxy)-ethyl)-benzene Prepared in analogy to example 16a) from 1-(3-fluoro-phenyl)-ethanol (Balasubramanian et al., Synth. Commun., 1994, 24 (8), 1049) and 4-nitrophenol. Yellow oil. Yield=77%. MS: m/e=261.2 (M+).

According to the analysis of related databases, 402-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jolidon, Synese; Rodriguez Sarmiento, Rosa Maria; Thomas, Andrew William; Wyler, Rene; US2003/232883; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts