Some common heterocyclic compound, 575-03-1, molecular formula is C10H5F3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.575-03-1
take 2.3g (O. Olmol) 4-trifluoromethyl _7_ hydroxy coumarin in a round bottom flask, followed by adding 3.5g (0 ¡¤ 025mol) K2C03, 0 ¡¤ 33g (0 ¡¤ OOlmol) Tetrabenzo Ammonium bromide, and 30mL of acetone, magnetic stirring to make it mix well, and then add 0.02g KI as a catalyst;2. The mixed solution was heated at 60¡ãC under stirring, after 15 min 1.6 mL (0.015 mol) of 1-Bromobutane was added, then stirred and refluxed for 6h, TCL monitered the progress of the reaction.3. After the reaction, the filtrate was filtered to remove insolubles such as potassium carbonate, and concentrated by rotary evaporation to give crude product d-1, which was recrystallized from ethanol / water to give compound d-1,4-trifluoromethyl-7- Lutein.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 575-03-1.
Reference:
Patent; (19 pag.)CN107674055; (2018); A;,
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