Month: October 2020

627-18-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-18-9, name is 3-Bromopropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

In a 500 mL round-bottom flask, 3-bromopropan-1-ol (12.4 g, 89.2 mmol, 1 eq.) was dissolved in acetone (200 mL). A solution of sodium azide (29.0 g, 466 mmol, 5.2 e.) in deionized water (120 mL) was added while stirring. A catalytic amount of Kl (approximately 2 mg) was added. This solution was stirred at room temperature for 48 hours. After extraction with diethyl ether (3 x 80 mL), the combined organic layers were dryed over K2CO3. The drying agent was filtered off and the solvent evaporated in vacuo to give 3-azidopropan-1-ol as a highly viscous colourless oil (8.09 g, 80.0 mmol, 90 %). HRMS ESI(+) (MeOH) calculated for [M+Na]+: 124.04813, found: 124.04790.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-18-9, 3-Bromopropan-1-ol.

Reference:
Patent; Universitaet Zuerich; GADEMANN, Karl; BERG, Regina; MEIER, Andrea; (43 pag.)EP3508492; (2019); A1;,
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42822-86-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 42822-86-6, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, molecular formula is C10H20O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: para-Methane-3,8-diol (3, 5.0 g, 0.029 mol) and an appropriatemolar equivalence of acid anhydride were transferred into thereactor concurrently. Both reagents were stirred and heated at60 Cfor 10 minutes. The homogeneous mixture was achievedand 0.3 g of polymer-bound scandium triflate (PS-Sc(OTf)3)catalyst was added into the reaction mixture. The reaction wasstirred 60 Cfor 24 hours, while followed by sampling at anhourly interval. Upon the completion of the reaction, the catalyst was separated from the product mixture by filtration and theacid was removed by distillation. The obtained crude samplewas purified by column chromatography hexane/EtOAc (98:2).The colourless oily products were analysed.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 42822-86-6, 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mafu, Lubabalo; Zeelie, Ben; Watts, Paul; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2046 – 2054;,
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372-30-5 , The common heterocyclic compound, 372-30-5, name is Ethyl 4,4,4-trifluoro-3-hydroxybutyrate, molecular formula is C6H9F3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of ethyl 4,4,4-trifluoro-3-hydroxybutanoate (3.0 g, 16.1 mmol) in MeOH (8 mL) was stirred with aqueous ammonium (16 mL) at room temperature overnight. The mixture was concentrated to afford 4,4,4-trifluoro-3-hydroxybutanamide (2.19 g, yield: 87.6%).

The synthetic route of 372-30-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; FENG, Song; GAO, LU; HONG, Di; WANG, Lisha; YUN, Hongying; ZHAO, Shu-Hai; (89 pag.)US2016/200741; (2016); A1;,
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597-31-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.597-31-9, name is 3-Hydroxy-2,2-dimethylpropanal, molecular formula is C5H10O2, molecular weight is 102.1317, as common compound, the synthetic route is as follows.

The hydrogenation feed as described in example 1 was used.Catalyst UsedThe catalyst from example 1 was used.HydrogenationThe hydrogenation input was passed in the downflow mode at an H2 pressure of 37 bar through the reactor which was heated to 105 C. The WHSV was 0.32 kg of HPA/(kgcat*h). From 0 to 17% by weight (based on the hydrogenation feed) of a 50% strength by weight aqueous solution of trimethylamine were added to this mixture in order to set a pH of the hydrogenation output of greater than 8 (hydrogen/hydroxypivalaldehyde molar ratio: about 1.5). Part of the hydrogenation output was mixed back into the input (recycle mode). The ratio of recycle to input was 16:1. A mean conversion of 88.1% at a mean pH of 8.4 were achieved over a number of days.

Statistics shows that 597-31-9 is playing an increasingly important role. we look forward to future research findings about 3-Hydroxy-2,2-dimethylpropanal.

Reference:
Patent; BASF Aktiengesellschaft; US2007/282135; (2007); A1;,
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95-12-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 95-12-5, name is Bicyclo[2.2.1]hept-5-en-2-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 2; Synthesis of Norbornene Monomers Containing Olefin Side Chain (NBMOAC); The procedure for synthesizing norbornene monomers containing olefin side chain was as following scheme: Norbornene methylene alcohol (11.2 g, 0.1 mol) and little hydroquinone were dissolved in 20 ml of tetrahydrofuran in a two-mouth bottle. The mixture of methylacrylethoxy isocyanate (15.0 g, 0.1 mol excess) and tetrahydrofuran (15 ml) were dropwise added into the solution with a funnel at rate of 1 drop/sec. The mixture was heated to reflux with stirring at 50 C. for 6 h. Small amount of methanol was then added to react with rest methylacrylethoxy isocyanate and the solution became transparent. Solvent was then removed by rotational evaporation to give pale white liquid. A white solid formed from said pale white liquid after a period of time without any disturbance.After comparison of practical atom analysis and theoretical distribution we found that the theoretical distribution of monomer norbornene containing olefin end (C15H21O4N) was C=64.52%, H=7.52%, N=5.02%; while the practical analysis was C=64.07%, H=7.50%, N=4.98%.The NMR spectrum of monomer norbornene containing olefin end was as following: 1H NMR(CDCl3): delta (ppm)=0.44-0.46(Hn3n), 1.06-1.08(Hx3x), 1.14-1.16(Hn7a), 1.22-1.24(H3), 1.33-1.35(Hn7s), 1.59(Hx2n), 1.70-1.74(Hn3x), 1.83-1.89(H10), 2.27(Hn2x), 2.60(Hx4), 2.70-2.71(Hn4, Hx1), 2.76(Hn1), 3.39-3.40(Hn8), 3.51-3.55(H12), 3.73-3.77(H13), 4.11-4.15(Hx8), 5.50, 5.85(H11, CC), 5.98(Hn6), 6.01(Hx6,Hx5), 6.04(Hn5). 13C NMR(CDCl3): delta (ppm)=18.53(C10), 29.20(Cn3), 29.78(Cx3), 38.46(Cx2), 39.59(Cn2), 40.39(C12), 41.88(C13), 42.50(Cx1,Cn4), 43.90, 44.16(Cx4, Cn1), 45.25(Cx7), 49.66(Cn7), 64.01(Cn8), 68.69(Cx8), 126.20(C11), 132.50(Cn6), 136.46-136.51(Cx5,Cx6), 137.21(Cn5) 137.77(C14), 157.09(C15), 167.57(C16).IR analysis for monomer norbornene with olefin end was as following:3360(upsilonN-H), 3050(upsilonC-H), 2960(upsilonC-H), 1715(upsilonCO), 1640(upsilonCC), 1540(upsilonC-H), 1300(upsilonC-O).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 95-12-5, Bicyclo[2.2.1]hept-5-en-2-ylmethanol.

Reference:
Patent; National Taiwan University of Science & Technology; US7132565; (2006); B2;,
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Adding some certain compound to certain chemical reactions, such as: 4415-82-1, name is Cyclobutylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4415-82-1. 4415-82-1

General procedure: To a stirred solution of alcohol 9 (8.00mmol) in toluene (40mL) under argon were added sequentially diethyl phosphonoacetic acid (1.35mL, 8.40mmol), DIPEA (3.62mL, 20.8mmol) and propyl phosphonic anhydride (6.62g, 10.4mmol, 50% w/w solution in ethyl acetate/THF). The solution was stirred at rt for 4h after which time it was diluted with water (50mL) and extracted with ethyl acetate (3¡Á100mL) followed by sequential washing of the combined organic extracts with 10% aqHCl (50mL), satd aqNaHCO3 (50mL) and brine (50mL). The organic extracts were dried over MgSO4 and concentrated in vacuo, affording the alpha-(diethoxyphosphoryl)acetate product 10, which was used without further purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4415-82-1.

Reference:
Article; Lloyd, Matthew G.; D’Acunto, Mariantonietta; Taylor, Richard J.K.; Unsworth, William P.; Tetrahedron; vol. 71; 39; (2015); p. 7107 – 7123;,
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558-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-hydroxy-3,5-dimethylbenzonitrile (2.00 g, 13.5 mmol) and 1-chloro-2-methyl propan-2-ol (8.85 g, 81.5 mmol) in ethanol (50 mL) was added potassium carbonate (7.5 g, 54 mmol) and water (5 mL). The reaction mixture was stirred at reflux for 24 h and cooled to room temperature. The precipitated solid was filtered off and washed with water. The solid was dissolved in ethyl acetate (100 mL), washed with water (50 mL), brine (50 mL), and dried over anhydrous Na2SO4. Removal of solvent gave 4-(2-hydroxy-2-methylpropoxy)-3,5-dimethyl benzonitrile (2.9 g, 97percent) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 558-42-9, 1-Chloro-2-methyl-2-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald; US2013/281397; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 623-04-1, (4-Aminophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-04-1, blongs to alcohols-buliding-blocks compound. 623-04-1

a tert-Butyl N-(4-(hydroxymethyl)phenyl)carbamate (4-Aminophenyl)methanol (1.23 g, 10 mmol) and diisopropylethylamine (2.6 mL, 15 mmol) was mixed with di-tert-butyl dicarbonate (2.62 g, 12 mmol) in dichloromethane (50 mL). The mixture was stirred at room temperature overnight. Ethyl acetate was added and the organic layer was washed with water, 1.0N HCl, saturated sodium carbonate, water, brine, dried over MgSO4, filtered and evaporated. The crude product was purified by flash column chromatography with Ethyl acetate/heptane (2:3) to give tert-butyl N-(4-(hydroxymethyl)phenyl)carbamate (2.16 g, 9.67 mmol). 1H NMR (CDCl-d) delta1.52 (s, 9H), 4.63 (s, 2H), 6.47 (bs, 1H), 7.30 (d, 8.5 Hz, 2H), 7.36 (d, 8.5 Hz,2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-04-1, its application will become more common.

Reference:
Patent; Hirst, Gavin C.; Calderwood, David; Munschauer, Rainer; Arnold, Lee D.; Johnston, David N.; Rafferty, Paul; US2003/153752; (2003); A1;,
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56-81-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56-81-5, name is Propane-1,2,3-triol, molecular formula is C3H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Diols and polyol reactants (100 mg) were allowed to react with benzoic anhydride (1.1 equiv) in acetonitrile (1 mL) at 40C for 8-12 h in the presence of TBAOBz (0.2 equiv). The reaction mixture was directly purified by flash column chromatography (hexanes/EtOAc=2:1 to 1:1), affording the pure selectively protected derivatives.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56-81-5, Propane-1,2,3-triol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Xiaoling; Ren, Bo; Ge, Jiantao; Pei, Zhichao; Dong, Hai; Tetrahedron; vol. 72; 7; (2016); p. 1005 – 1010;,
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627-30-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-30-5, name is 3-Chloropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

In a flask, 10.0 g (0.058 mol) of the compound represented by the formula (I-1a), 7.10 g (0.075 mol) of 3-chloropropanol, potassium carbonate 11.99 g (0.087 mol), and 100 mL of ethanol were added and heated under reflux for 5 days. After filtration, the solvent was distilled off and redissolved in toluene. After washing with brine, purification by column chromatography (silica gel) gave 10.7 g (0.046 mol) of the compound represented by the formula (I-11a).

Statistics shows that 627-30-5 is playing an increasingly important role. we look forward to future research findings about 3-Chloropropan-1-ol.

Reference:
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; HAYASHI, MASANAO; KUSUMOTO, TETSUO; (90 pag.)JP6102423; (2017); B2;,
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