The common heterocyclic compound, 870-72-4, name is Hydroxymethanesulfonic Acid Sodium Salt, molecular formula is CH3NaO4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 870-72-4
a) 28.1 parts of 4-(beta-sulfatoethylsulfonyl)-aniline are suspended in 70 parts of ice/water and 18 parts of 30% strength hydrochloric acid and diazotized by dropwise addition of 17.5 parts of 40% strength sodium nitrite solution. Following removal of the excess nitrite with amidosulfonic acid solution, the resulting diazo suspension is admixed with an aqueous solution of 33.3 parts of 4-hydroxy-7-(sulfomethyl-amino)-naphthalene-2-sulfonic acid, which has been obtained by reaction of 23.9 parts of 7-amino-4-hydroxy-naphthalene-2-sulfonic acid with 15 parts of formaldehyde-sodium bisulfite in aqueous medium at a pH of 5.5-6 and at 45 C., and is adjusted to a pH of 1.5 using solid sodium hydrogen carbonate. This is followed by stirring at a pH of 1.5 and at 15-20 C. until the acidic coupling reaction is at an end.
The synthetic route of 870-72-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DYSTAR COLOURS DEUTSCHLAND GMBH; US2011/283465; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts