Adding a certain compound to certain chemical reactions, such as: 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 647-42-7, blongs to alcohols-buliding-blocks compound. 647-42-7
General procedure: A dry flask was charged with THF (9 mL), NaOH pellets (0.48 g, 12 mmol), and perfluorohexylethanol or perfluoroheptylmethanol (3 mmol). The flask was immersed in an ice-bath and the contents stirred for 10 min. Propargyl bromide (0.54 g, 4.5 mmol) was added dropwise and the reaction mixture stirred and gradually allowed to warm to r.t. over 24 h. The reaction mixture was poured into Et2O (20 mL) and water (50 mL), the layers separated and the aqueous layer extracted with more Et2O (3 ¡Á 20 mL). The combined organic extracts were washed with 10% HCl soln. followed by sat. aq. NaHCO3 and brine, and then dried over Na2SO4. Column chromatography (silica gel, Et2O/LP, 10:90) followed by Kulgelrohr distillation gave the desired products.
With the rapid development of chemical substances, we look forward to future research findings about 647-42-7.
Reference:
Article; Francis, Dominic V.; Miles, D. Howard; Mohammed, Adnan I.; Read, Roger W.; Wang, Xiaobei; Journal of Fluorine Chemistry; vol. 132; 11; (2011); p. 898 – 906;,
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