100-37-8, Adding a certain compound to certain chemical reactions, such as: 100-37-8, 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100-37-8, blongs to alcohols-buliding-blocks compound.
34.9 g (0.1 mol) of 4- [1- (5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl) ethenyl] benzoic acid (bexarotene; Targretin )) Was dissolved in 300 ml of chloroform.To this reaction mixture was added 20.6 g of N, N’-dicyclohexylcarbodiimide.11.6 g of dimethylaminoethanol was added to the reaction mixture. The mixture was stirred at room temperature for 3 hours. Solids were removed by filtration.The chloroform solution was washed with 5% NaHCO 3 (2 ¡Á 10 0 ml) and water (3 ¡Á 100 ml).The organic solution was dried over anhydrous sodium sulfate.Sodium sulfate was removed by filtration. To this reaction mixture 3.6 g of HCl gas / ether (100 ml) was added with stirring. The solid product was collected by filtration. After drying 40 g of the desired product (85.8%) was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.
Reference:
Patent; YU, CHONGXI; (76 pag.)JP2017/160261; (2017); A;,
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