623-04-1, Adding some certain compound to certain chemical reactions, such as: 623-04-1, name is (4-Aminophenyl)methanol,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 623-04-1.
2.15g (17.5mmol) of 4-aminobenzyl alcohol was added to 20mL of 10% HCl aqueous solution at 0C, followed by addition of 1.45g (21.0mmol, 1.2equiv) sodium nitrite dissolved in dry 10mL CH2Cl2. After the mixture was stirred at 0C for 1h, 4mL of sodium azide (1.88g, 28.9mmol) aqueous solution was added drop-wise and stirred overnight. Then, the mixture was quenched with brine and extracted with ethyl acetate (100mL¡Á3). The combined organic layer was dried over anhydrous sodium sulfate and concentrated in vacuum. Finally, the crude product was purified by flash chromatography (petroleum/ethyl acetate=4:1) to give a yellow oil (2.21g, 85%). 1H NMR (400MHz, DMSO): delta=6.95 (d, J=8Hz, 2H), 6.50 (d, J=8Hz, 2H), 4.92 (s, 2H), 4.79 (t, J=8Hz, 1H), 4.28 (d, J=8Hz, 2H) (Fig.S3). 13C NMR (100MHz, DMSO): delta=145.97, 131.13, 128.78, 115.20, 65.16 (Fig.S4)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 623-04-1.
Reference:
Article; Xiang, Kaiqiang; Liu, Yunchang; Li, Changjiang; Tian, Baozhu; Tong, Tianzhong; Zhang, Jinlong; Dyes and Pigments; vol. 123; (2015); p. 78 – 84;,
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