2854-16-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a suspension of 2,4,6,8-tetrachloro-pyrimido[5,4-djpyrimidine (1) (3.50 g,i3.Oi mmol) in THF (200 mL) at -78¡ãC, i-amino-2-methyl-propan-2-ol (i.i7 mL, i2.36 mmol) in THF (20 mL) was added via syringe pump (during about 30 mm) followed byDIPEA (2.93 mL, i6.9i mmol) in THF (20 mL). The reaction mixture was stirred at -78¡ãC for additional 30 mi and then allowed to reach the room temperature. Water (250 mL) was added and the resulting suspension was extracted with EtOAc (3 x iOO mL). The combined organic extracts were washed with water (iSO mL), then with brine (iSO mL) and dried over solid anhydrous MgSO4. After filtration, the solvent was removed and the residue waspurified by flash column chromatography using gradient elution from PE/EtOAc (iO:4) toPE/EtOAc (i : i) to give 2-methyl-i -(2,6,8-trichloro-pyrimido[5,4-djpyrimidin-4-ylamino)-propan-2-ol (29)(3.67 g, 92percent yield). 300 MHz ?H NMR (CDC13, ppm): 7.70-7.58 (iH, m)3.70 (2H, d, J=6.i Hz) i.80 (iH, s) i.36 (6H, s). ESI-MS (m/z): 322, 324, 326, 328 [M+Hf?.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2854-16-2, 1-Amino-2-methylpropan-2-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GALLEON PHARMACEUTICALS, INC.; DAX, Scott L.; MENCEL, James Joseph; OZOLA, Vita; SUNA, Edgars; SHUBIN, Kirill; (294 pag.)WO2017/3822; (2017); A1;,
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