2050-25-1, Adding a certain compound to certain chemical reactions, such as: 2050-25-1, 2-(2-(Benzyloxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2050-25-1, blongs to alcohols-buliding-blocks compound.
Step A; 2-[2-(2-Benzyloxyethoxy)ethoxy]benzonitrile; [Show Image] [Show Image] 2-Hydroxybenzonitrile (300 mg, 2.52 mmol), di(ethylene glycol) benzyl ether (593 mg, 3.02 mmol), and 1,1′-azobis(N,N-dimethylformamide) (867 mg, 5.04 mmol) were dissolved in toluene (15 ml). Thereafter, tri-n-butylphosphine (1.26 ml, 5.04 mmol) was added at 20C to the obtained solution, and the obtained mixture was stirred at the same above temperature for 2 hours. The generated precipitate was filtrated, and the filtrate was then diluted with ethyl acetate (20 ml). The ethyl acetate solution was washed with water twice, and then with a saturated saline solution once. The resultant was dried over anhydrous sodium sulfate, and was then concentrated under reduced pressure. The obtained pale brown oil product was purified by silica gel column chromatography (dichloromethane), so as to obtain 2-[2-(2-benzyloxyethoxy)ethoxy]benzonitrile (529 mg, 71%) in the form of a colorless oil product. 1H-NMR (400MHz, CDCl3) delta (ppm): 3.65-3.67 (2H, m), 3.79-3.81 (2H, m), 3.93 (2H, t, J=5.0Hz), 4.24 (2H, t, J=5.0Hz), 4.57 (2H, s), 6.88 (1H, d, J=7.5Hz), 6.99 (1H, t, J=7.5Hz), 7.26-7.35 (5H, m), 7.49 (1H, t, J=7.5Hz), 7.54 (1H, d, J=7.5Hz) ESI (LC-MS positive mode) m/z 298 (M+H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2050-25-1, its application will become more common.
Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP1854792; (2007); A1;,
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