Adding some certain compound to certain chemical reactions, such as: 4415-82-1, name is Cyclobutylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4415-82-1. 4415-82-1
General procedure: To a stirred solution of alcohol 9 (8.00mmol) in toluene (40mL) under argon were added sequentially diethyl phosphonoacetic acid (1.35mL, 8.40mmol), DIPEA (3.62mL, 20.8mmol) and propyl phosphonic anhydride (6.62g, 10.4mmol, 50% w/w solution in ethyl acetate/THF). The solution was stirred at rt for 4h after which time it was diluted with water (50mL) and extracted with ethyl acetate (3¡Á100mL) followed by sequential washing of the combined organic extracts with 10% aqHCl (50mL), satd aqNaHCO3 (50mL) and brine (50mL). The organic extracts were dried over MgSO4 and concentrated in vacuo, affording the alpha-(diethoxyphosphoryl)acetate product 10, which was used without further purification.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4415-82-1.
Reference:
Article; Lloyd, Matthew G.; D’Acunto, Mariantonietta; Taylor, Richard J.K.; Unsworth, William P.; Tetrahedron; vol. 71; 39; (2015); p. 7107 – 7123;,
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