In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 702-23-8 as follows., 702-23-8
In a three-neckflask, 2-(4-methoxyphenyl)ethanol (2a, 3.00 g, 1 eq.) andtriphenylphosphine (6.72 g, 1.3 eq.) were dissolved in dryCH2Cl2 (25 ml). In an addition funnel, carbon tetrabromide(8.50 g, 1.3 eq.) was dissolved in dry CH2Cl2 (15 ml) andadded dropwise under inert atmosphere at 0 C until theaddition was complete. The reaction was allowed to stirat room temperature for an additional 4 h, or until completedisappearance of starting materials from thin-layerchromatography (TLC). The solvent was removed underreduced pressure, and the residue was purified by column chromatography using hexane and EtOAc to yield 3a as aclear oil. Yield: 4.11 g (97 %). 1H NMR (CDCl3) delta (ppm):3.08-3.12 (t, 2H), 3.51-3.55 (t, 2H), 3.79 (s, 3H), 6.85-6.87 (d, 2H), 7.12-7.14 (d, 2H).
The chemical industry reduces the impact on the environment during synthesis 702-23-8, I believe this compound will play a more active role in future production and life.
Reference:
Article; Do, Quang; Nguyen, Giang T.; Phillips, Robert S.; Amino Acids; vol. 48; 9; (2016); p. 2243 – 2251;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts