56456-49-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56456-49-6, name is 4-Chloro-2-fluorobenzyl alcohol, the common compound, a new synthetic route is introduced below.
25 mg of Triphosgene was dissolved in 0.5 ml of dichloromethane, 5 mul of pyridine was added, and a solution of 20 mg of ethyl-3-(3-aminophenyl)-2-isopropoxypropanoate in dichloromethane and 50 mul of triethylamine were added under ice-cooling. After the insoluble substances had been removed by cotton plug filtration, 15 mg of 2-fluoro-4-chlorobenzyl alcohol was added. The solvent was removed under a stream of nitrogen, and the residue was dissolved in 0.6 ml of ethanol. 0.12 ml of 5N sodium hydroxide was added, followed by stirring at room temperature for 1 hour. The reaction solution was treated with 1 ml of water and 0.14 ml of 5N hydrochloric acid, then extracted with ethyl acetate. The organic layers were collected, and the solvent was removed under a stream of nitrogen. The residue was purified by reverse-phase HPLC using a water-acetonitrile-trifluoroacetic acid solvent system, to give 1.4 mg of the title compound. MS m/e(ESI) 438 (MNa+)
Statistics shows that 56456-49-6 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-2-fluorobenzyl alcohol.
Reference:
Patent; Eisai Co., Ltd.; EP1380562; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts