100-37-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below.
General procedure: To tetrahydrofuran (THF) (1 mL) in a microwave reaction vessel were added cyclopentanol (0.067 mL, 0.74 mmol) and NaH (0.040 g, 1.68 mmol). After the reaction mixture was stirred at room temperature for 10 min, 2,6-dichloropyrazine (0.10 g, 0.67 mmol) was added and the resulting reaction mixture was heated in the microwave reactor at power 100 W and 50 C for 10 min. After removal of solvent in vacuo, the residue was treated with ethyl acetate and water mixture. Organic layer was collected and dried over anhydrous sodium sulfate. Removal of solvent in vacuo gave 2-chloro-6-(cyclopentyloxy)pyrazine 0.148 g in quantitative yield;
At the same time, in my other blogs, there are other synthetic methods of this type of compound,100-37-8, 2-(Diethylamino)ethanol, and friends who are interested can also refer to it.
Reference:
Article; Lee, Jinho; Park, Jongseong; Hong, Victor Sukbong; Chemical and Pharmaceutical Bulletin; vol. 62; 9; (2014); p. 906 – 914;,
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