575-03-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.
1. 2.3 g (0.0100 mol) of 4-trifluoromethyl-7-hydroxycoumarin (a-1) was taken in a round bottom flask, followed by the addition of 3.5g (0.025mol) of K2CO3, 0.33g (0 ? 001mol) of tetrabutylammonium br omide, and 30mL of acetone, the mixture is mixed under magnetic stirring, then 0.02 g KI was added as a catalyst;2. The mixed solution was heated at 60¡ãC under stirring, after 15 min 1.3 mL (0,015 mol) allyl bromide was added, then stirred and refluxed for 6h, TCL monitered the progress of the reaction3. After the reaction is completed, the insoluble matter such as potassium carbonate is removed by filtration and concentrated by rotary evaporation to obtain a crude product b-1, which is recrystallized from ethanol / water to give compound b-1,4-trifluoromethyl-7-allyloxy Lutein
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Reference:
Patent; (19 pag.)CN107674055; (2018); A;,
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