24034-73-9, Adding a certain compound to certain chemical reactions, such as: 24034-73-9, (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 24034-73-9, blongs to alcohols-buliding-blocks compound.
Error Objects cannot be created from editing field codes. [0306] Ethyl 2E,6E,10E-geranylgeranyl carbamate (7a) (R= Ethyl-): A dry reaction flask equipped with a stir bar, 2 inlet was charged with alcohol 1 (0.060 g, 0.2 mmol), pyridine (0.032 mL, 0.4 m mol) and DCM (2 m L). After cooling it to 0 C, ethyl isocyanate was added dropwise and the resulting reaction mixture was allowed to stir for 24 h. The reaction was monitored by TLC. After completion of the reaction, it was quenched with H20 (5 mL), acidified, extracted with n-hexanes (3 x 15 mL) and the combined n-hexanes were washed with H20 (10 mL). After drying the organic solution over anhydrous a2S04, the solvent was evaporated and the resulting residue was purified by silica gel column chromatography using 1-2% EtOAc in n-hexanes to afford the desired carbamate 7a. Yield: 0.039g (54%); TLC f: 0.30 (10% EtOAc/n-Hexanes); LCMS: MS (m/z): 384 (M + IMa); ret. time: 14.39 min. [0307] The following carbamates 7b to 7z were prepared according to the procedu re that was used to prepare carbamate 7a.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,24034-73-9, its application will become more common.
Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush B.; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian; WO2013/130654; (2013); A1;,
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