41175-50-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, the common compound, a new synthetic route is introduced below.
(b) Take 2mL of anhydrous N,N-dimethylformamide, under ice bath and nitrogen protection, add phosphorus oxychloride (4mL) dropwise, stir for 30min, and add dropwise to the solution of intermediate 9 (1g Intermediate 9 was dissolved in 2 mL of anhydrous N,N-dimethylformamide), and after stirring for 10 min, the temperature was raised to 60C and the reaction was performed for 12 h. After cooling to room temperature, the reaction solution was poured into ice water, 1M NaOH was added to adjust the pH to 5-6. After standing for a period of time, a precipitate precipitated out, the reaction solution was suction filtered, and the crude product was obtained after drying, using column chromatography After purification, the eluent was methanol/dichloromethane (1:60) to obtain 0.9 g of a light green solid, that is, intermediate 10.
Statistics shows that 41175-50-2 is playing an increasingly important role. we look forward to future research findings about 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol.
Reference:
Patent; Sun Yat-sen University; Tan Jiaheng; Huang Zhishu; Yu Zeyi; Luo Wenhua; Chen Shuobin; (18 pag.)CN111116573; (2020); A;,
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