53066-19-6 , The common heterocyclic compound, 53066-19-6, name is 1-(2,6-Dichlorophenyl)ethanol, molecular formula is C8H8Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 1 -(2,6-dichlorophenyl)ethanol (9.0 g, 47.11 mmol) in THF (200 niL) at 0 C was added NaH (60% dispersion in mineral oil, 2.45 g, 61.24 mmol) inportions. When the evolution of gas bubble stopped, a solution of 3-fluoro-2-nitropyridine (6.69 g, 47.11 mmol) in THF (50 mL) was added to the system. The reaction was stirred at room temperature overnight, then quenched with H20 (10 mL) at 0 C, and concentrated in vacuo. The residue was diluted with H 0 (200 mL), and extracted with EtOAc (150 mL x 3). The combined organic phases were washed with saturated aqueous aHC03 (200 mL) followed by brine (200 mL), dried over anhydrous a2S04, filtered and concentrated in vacuo to give the title compound as a brown solid (14.34g,97.2%).
According to the analysis of related databases, 53066-19-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; WANG, Ruyong; WANG, Liang; WO2014/89324; (2014); A1;,
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