Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 929-06-6, name is 2-(2-Aminoethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. 929-06-6
To the solution of dioxane (40 mL), H20 (20 mL) and NaOH ( 20 mL; 1 M) was added 2-(2- aminoetoxy) ethanol. The reaction mixture was cooled to 0C and di-t-Bu dicarbonate ( 4,8 g) was added. The mixture was stirred for 30 min at 0C, and then the stirring was continued for 2 hours at room temperature. In next 3 hours two portion of di-t-Bu dicarbonate ( 2x 0,22 g) were added. The mixture was stirred over night at room temperature and then concentrated (20-30 mL). EtOAc (60 mL) was added to the solution and pH was adjusted to 2.5. Aqueous layer was extracted with EtOAc (3×20 mL). Organic layers was washed with H2O (3×30 mL), dried over KzC03 and evaporated in vacuum to give 3,7 g of the title product as oil.
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Reference:
Patent; PLIVA-ISTRAZIVACKI INSTITUT D.O.O.; WO2005/108412; (2005); A1;,
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