7287-81-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7287-81-2, name is 1-(m-Tolyl)ethanol. A new synthetic method of this compound is introduced below.
General procedure: A 1,2-dichloroethane (2.0 mL) solution of alcohol 1 (0.3 mmol), enol acetate 2 (0.3 mmol), andReBr(CO)5 (5 mol%) was stirred under an atmosphere of nitrogen at 80 C for 5 h. After the reactionwas complete, H2O was added to the reaction mixture and extracted with ethyl acetate. The organiclayer was dried with MgSO4. The resulting mixture was filtered, and the filtrate was concentrated.Purification of the residue by silica gel column chromatography afforded carbonyl compounds.Further purification was carried out by recyclable preparative HPLC, if necessary. The structures ofthe products were assigned by their 1H and 13C-NMR, and mass spectra. The product was characterizedby comparing its spectral data with those of authentic sample or previous reports 3a,S1 3b,S2 3c,S2a3d,S2a,S3 3f,S4 3h,S5 3i,S6 3j,S7 3k,S4 3l,S8 3m,S9 3n,S2a 3o,S5 3q,S10 3t,S2a,S11 and 3u. S12 The structures of theproducts (3g, 3o, 3p, 3q, 3r, 3s, and 3v) were assigned by their 1H and 13C NMR, IR and mass spectra
At the same time, in my other blogs, there are other synthetic methods of this type of compound,7287-81-2, 1-(m-Tolyl)ethanol, and friends who are interested can also refer to it.
Reference:
Article; Umeda, Rui; Takahashi, Yuuki; Nishiyama, Yutaka; Tetrahedron Letters; vol. 55; 44; (2014); p. 6113 – 6116;,
Alcohol – Wikipedia,
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