A common compound: 13401-56-4, name is 3-Chloro-2,2-dimethylpropan-1-ol,molecular formula is C5H11ClO, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 13401-56-4
Example 1; :3-iodo-2,2-dimethyl-1-propandioxolane (formula (IVA))A); Preparation according to scheme 5: a) 3-iodo-2,2-dimethyl-propanol (formula (VI): X=I (VIC)): 80 g (0.53 mol) of dry Nal and 5 g (0.03 mol) of K2CO3 are added under argon to a solution of 50 g (0.4 mol) of 3-chloro-2,2-dimethyl-1-propanol (formula VIA) in 75 ml of DMF. The mixture is stirred at reflux for 8 hours. The reaction mixture is subsequently brought to room temperature and diluted by addition of 500 ml of water. The organic phase is extracted with 1050 ml of ethyl acetate, washed with a saturated aqueous solution of Na2SO3, then with a 250 ml of a saturated solution of sodium bicarbonate dried over 60 g of anhydrous magnesium sulfate and evaporated to give crude compound of formula (VIC). H1RMN delta ppm : 0.97 (s,6H,CH3); 2.48 (s, broad, OH) ; 3.17 (s, 2H, CH2); 3.37 (s,2H, CH2). 13C RMN delta ppm : 20.3 (CH2l); 23.7 (2C,CH3); 35.5 (q, 1C) ; 69.7 (CH20)
With the rapid development of chemical substances, we look forward to future research findings about 13401-56-4.
Reference:
Patent; Merck Sante; EP1591434; (2005); A1;,
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