Alcohols-buliding-blocks

NIR light and enzyme dual stimuli-responsive amphiphilic diblock copolymer assemblies was written by Wang, Jilei;Wu, Bing;Li, Shang;He, Yaning. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2017.Electric Literature of C7H7NO4 This article mentions the following:

Using atom transfer radical polymerization (ATRP) and macromol. azo coupling reaction, both o-nitrobenzyl (ONB) group and azobenzene group were efficiently incorporated into the center of the amphiphilic diblock copolymer chain. The prepared diblock copolymer was well characterized by UV-vis, ¹H NMR, and GPC methods. Self-assembly of the amphiphilic copolymer in selected solvents can result in uniform self-assembly aggregates. In the presence of external stimuli [upconversion nanoparticles (UCNPs)/NIR light or enzyme], the amphiphilic diblock copolymer chain could be broken by the cleavage of ONB or azobenzene group, which would lead to the disruption of the self-assembly aggregates. This photo- and enzyme-triggered disruption process was proved by using transmission electron microscopy (TEM) and GPC method. Fluorescence emission spectra measurements indicated that the release of Nile red, a hydrophobic dye, encapsulated by the self-assembly aggregates, could be successfully realized under the NIR light and enzyme stimuli. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Electric Literature of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dehydration of terpin hydrate in the presence of various ion-exchange resins was written by Isagulyants, V. I.;Fedorova, R. I.. And the article was included in Tr., Mosk. Inst. Neftekhim. iGaz. Prom. in 1964.Formula: C10H22O3 This article mentions the following:

During dehydration of terpin hydrate in the presence of cation exchange KU-2 (2%) as catalyst, dl-α-terpineol (I) was obtained in 62% yield. Cineole was not found. In the presence of cation exchanger KU-1 under the same conditions the yield of I was 37%. Best results were obtained in the presence of a sulfocarbon (10%) as catalyst. After 4 times the yield of I was 68% of the theoretical. In all cases I was distilled with water vapors as soon as it was formed to avoid its further possible dehydration to hydrocarbons. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Formula: C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qualitative and quantitative analysis of the major components in Qinghao Biejia decoction by UPLC-Orbitrap Fusion-MS/MS and UPLC-QQQ-MS/MS and evaluation of their antibacterial activities was written by Cheng, Xin;Li, Biao-Ping;Han, Zhong-Xiao;Zhang, Feng-Lin;Jiang, Zhi-Rui;Yang, Jia-Shun;Luo, Qi-Zhi;Tang, Ling. And the article was included in Phytochemical Analysis in 2022.COA of Formula: C18H32CaN2O10 This article mentions the following:

In the present study, the chem. components of Qinghao Biejia decoction (QBD) were qual. and quant. analyzed using UPLC-Orbitrap Fusion-MS/MS and UPLC-QQQ-MS/MS techniques, followed by identification of each components origin and evaluation of the antibacterial activity of QBD and its components. High-resolution mass spectrometry was used to obtain information on the precise mol. weight, retention time, and fragmentation ion peaks of the compounds used to identify the components of QBD and establish a method for their quantification. In vitro assays including determination of the minimal inhibitory concentration and growth curves were used to assess the antibacterial activity of QBD and its components. A total of 39 components, including fatty acids, phenolic acids, amino acids, flavonoids, coumarins, terpenoids, and alkaloids, were identified by UPLC-Orbitrap Fusion-MS/MS. A high-performance anal. method was also established to quantify 12 components of QBD. The content of mangiferin was relatively high (estimated to be 814μg/g). The results of the antibacterial assays indicated that mangiferin exhibits antibacterial effects against two strains causing respiratory tract infections. The present study suggests that mangiferin may serve as a natural compound which shows high antibacterial activity. The results can aid the discovery and anal. of the active antimicrobial components present in QBD and further provide a reference for quality assessment of multi-component herbal prescriptions. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6COA of Formula: C18H32CaN2O10).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C18H32CaN2O10

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dual-responsive nanogels based on oligo(ethylene glycol) methacrylates and acidic co-monomers was written by Macchione, Micaela A.;Sacarelli, M. Florencia;Racca, Ana C.;Biglione, Catalina;Panzetta-Dutari, Graciela M.;Strumia, Miriam C.. And the article was included in Soft Matter in 2019.Formula: C16H26O7 This article mentions the following:

Ethylene glycol-based nanogels (NGs) have demonstrated their potential for the development of next-generation formulations for biomedical applications due to their interesting properties. In this work, monodispersed NGs based on oligo(ethylene glycol) methacrylates (OEG) were synthesized through free radical precipitation/dispersion polymerization assisted by ultrasonication. Di(ethylene glycol)methyl ether methacrylate (DEGMA) and oligo(ethylene glycol) methacrylate (OEGMA; M_n 475 g mol^-1) were used as the main monomers, acrylic acid (AA) or itaconic acid (IA) as co-monomers (OEG-co-AA and OEG-co-IA, resp.) and tetraethylene glycol dimethacrylate (TEGDMA) as crosslinker. The physicochem. properties of OEG-co-AA and OEG-co-IA NGs were studied including hydrodynamic diameter, poly-dispersity index, zeta potential and pH/temperature responsiveness. Samples with 4 mol% of both AA and IA showed nanometric sizes. Regarding their thermo-responsiveness, unexpected differences between NGs with AA or with IA were observed Besides, NGs did not impair the cell viability of a breast tumor cell line even when high concentrations were added to the culture medium. The properties of the synthesized NGs showed that either NGs with 4% AA or with 4% IA are outstanding candidates for biomedical applications. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Production of cultured fat with peanut wire-drawing protein scaffold and quality evaluation based on texture and volatile compounds analysis was written by Song, Wen-Juan;Liu, Pei-Pei;Zheng, Yan-Yan;Meng, Zi-Qing;Zhu, Hao-Zhe;Tang, Chang-Bo;Li, Hui-Xia;Ding, Shi-Jie;Zhou, Guang-Hong. And the article was included in Food Research International in 2022.COA of Formula: C8H16O This article mentions the following:

Cultured meat is an emergent technol. that cultivates cells in three-dimensional scaffolds to generate tissue for consumption. Fat makes an important contribution to the flavor and texture of traditional meat, but there are few reports on cultured fat. Here, we demonstrated the construction of cultured fat by inoculating porcine adipose-derived mesenchymal stem cell (ADSC) on peanut wire-drawing protein (PWP) scaffolds. First, we demonstrated that basic fibroblast growth factor (bFGF) promoted cell proliferation and maintained adipogenic differentiation ability. Then, we generated cultured fat and found that cultured fat decreased the texture of PWP scaffolds. Moreover, 43 volatile compounds were detected by headspace gas chromatog.-ion mobility spectrometry (GC-IMS), of which 17 volatile compounds showed no significant differences between cultured fat and porcine s.c. adipose tissue (pSAT), which indicated that cultured fat and pSAT had certain similarities. Collectively, this research has great promise for improving the quality of cultured meat. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4COA of Formula: C8H16O).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C8H16O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Determination of codeine in terpin hydrate and codeine elixir was written by Blake, Martin I.;Carlstedt, Bruce. And the article was included in Journal of Pharmaceutical Sciences in 1966.Computed Properties of C10H22O3 This article mentions the following:

Ion-exchange chromatography and nonaqueous titrimetry and applied to the analysis of codeine in terpin hydrate and codeine elixir. The method is simple and accurate. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Computed Properties of C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Development of a comprehensive quality control method for the quantitative analysis of volatiles and lignans in Magnolia biondii Pamp. by near infrared spectroscopy was written by Li, Junni;Wen, Jinfeng;Tang, Gengqiu;Li, Rong;Guo, Huanjia;Weng, Wenfeng;Wang, Dong;Ji, Shengguo. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

The quality of drug is vital to its curative effect, thus it is important to develop a comprehensive quality control method for commonly used drugs. In this study, we developed a Gas chromatog.-mass spectrometry separation method for the qual. and quant. anal. of volatiles, together with a High-performance liquid chromatog.-mass spectrometry separation method for lignans in Magnolia biondii Pamp.. 79 volatiles and 11 lignans were identified via comparing their chromatog. behavior and mass spectra data with those in the literature. The methods were then used to determine the contents of volatiles (1, 8-cineole, D-Limonene, α-terpineol, linalool, L-camphor and bornyl acetate) and lignans (epieudesmin, magnolin, epi-magnolin A and fargesin) in Magnolia biondii Pamp. Subsequently, 13 qual. models including volatiles (1, 8-cineole, D-Limonene, α-terpineol, linalool, L-camphor and bornyl acetate), water-soluble extractive, lignans (pinoresinol di-Me ether, magnolin, epi-magnolin A and fargesin) and moisture were developed by Near-IR Spectroscopy based on partial least square regression herein. The reference values were obtained by High-performance liquid chromatog., Gas chromatog. and etc., while the predicted values were attained from the NIR spectrum. Compared with the traditional detection methods, NIR technique methodol. significantly improved the ability to evaluate the quality of Magnolia biondii Pamp., which had the advantages of convenience, celerity, highly efficiency, low cost, no harm to samples, no reagent consumption, and no pollution to the environment. Moreover, the systematic anal. method combined pharmaceutical anal. with pharmacochem. was proposed to prepare volatiles, water-soluble extractive and lignans parts from the same sample. This way could extract more index components to be beneficial in the quality control of Magnolia biondii Pamp. roundly. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

N-Phosphorylated derivatives of 5-nitroindazole as antimicrobial and antioxidant agents and docking study against DNA gyrase A was written by Thaslim Basha, S. K.;Subba Rao, Devineni;Madhava, Golla;Basha, Shaik Thahir;Devamma, Mundla Nagalakshmi;Saddala, Madhu Sudhana;Asupatri, Usha Rani;Raju, Chamarthi Naga. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2015.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:

A series of new phosphoramidates I [R = (CH₂)₄N, O(CH₂CH₂)₂N, (CH₂)₅N, etc.] were synthesized by reacting 5-nitroindazole with 4-chlorophenyl dichlorophosphate, and then further with various bio-potent aromatic/hetero/alkyl amines. All the newly synthesized compounds were characterized by spectroscopic data (IR, ¹H, ¹³C, ³¹P NMR and mass) and elemental anal. The products were evaluated for their antioxidant activity (DPPH, H₂O₂ methods and IC₅₀ values) and antimicrobial activity against the growth of Gram bacterial (pos. and neg.) and fungal pathogens. In the entire bio-screening data, the authors observed that is the most active compound in terms of its antimicrobial and antioxidant activities. Further to know the binding interactions of title products with DNA gyrase A enzyme (E. coli), mol. docking studies were performed which revealed and exhibited high binding affinities towards the enzyme, DNA gyrase A, and are higher than that of the standard antibiotic, streptomycin. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of a Switch Between Prelog and Anti-Prelog Reduction toward Halogen-Substituted Acetophenones in Short-Chain Dehydrogenase/Reductases was written by Qin, Fengyu;Qin, Bin;Zhang, Wenhe;Liu, Yalin;Su, Xin;Zhu, Tianhui;Ouyang, Jingping;Guo, Jiyang;Li, Yuxin;Zhang, Feiting;Tang, Jun;Jia, Xian;You, Song. And the article was included in ACS Catalysis in 2018.Reference of 171032-87-4 This article mentions the following:

The application of ketoreductases based biocatalytic reduction to access optically pure Prelog or anti-Prelog alcs. offers a valuable approach for asym. synthesis. Despite this, control the stereopreferences of ketoreductases as desired remains challenging since natural ketoreductases usually display Prelog preference and it is difficult to transfer the knowledge from engineered anti-Prelog ketoreductases to the others. Here, we present the discovery of a switch between Prelog and anti-Prelog reduction toward halogen-substituted acetophenones in six short-chain dehydrogenase/reductases (SDRs). Through carefully analyzing the structural information and multiple-sequence alignment of several reported SDRs with Prelog or anti-Prelog stereopreference, the key residues that might control their stereopreferences were identified using Lactobacillus fermentum short-chain dehydrogenase/reductase 1 (LfSDR1) as the starting enzyme. Protein engineering at these positions of LfSDR1 could improve its anti-Prelog stereoselectivity or switch its stereopreference to Prelog. Moreover, the knowledge obtained from LfSDR1 could be further transferred to other five SDRs (four mined SDRs and one reported SDR) that have 21-48% sequence identities with LfSDR1. The stereopreferences of these SDRs were able to be switched either from anti-Prelog to Prelog or from Prelog to anti-Prelog by mutagenesis at related positions. In addition, further optimization of LfSDR1 can access stereo-complementary reduction of several halogen-substituted acetophenones with high stereoselectivity (up to >99%), resulting in some valuable chiral alcs. for synthesis of pharmaceutical agents. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Reference of 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A study of the aromatic constituents of Yunnan black tea by different extraction methods was written by Zhou, Bin;Ren, Hong-tao;Qin, Tai-feng;Xia, Kai-guo. And the article was included in Xiandai Shipin Keji in 2011.Recommanded Product: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

Yunnan black tea has a characteristic of heavy fragrant aroma. Little work has been done on the aromatic constituents of Yunnan black tea. Using three methods (simultaneous distillation extraction, acetone extraction and petroleum ether extraction), aromatic constituents of the Yunnan black tea were extracted and then analyzed by GC-MS. The result showed that different constituents are extracted by different methods. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Recommanded Product: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts